EC Psychology and Psychiatry

Research Article Volume 12 Issue 3 - 2023

Association of Lesion Location with Post-Stroke Depression in China: A Systematic Review and Meta-Analysis

Xinqun Luo1, Wenhua Fang1, Jiawu Ji2, Yong Zhang3, Rolando Garcia-Milian4, Zhiren Wang5, Yunlong Tan5, Shibin Wang6, Xiaoping Wang7*, Xiaoyun Guo6,8* and Xingguang Luo5*

1Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China

2Department of Psychiatry, Fujian Medical University Affiliated Fuzhou Neuropsychiatric Hospital, Fuzhou, Fujian, China

3Department of Bipolar Disorder, Tianjin Anding Hospital, Tianjin, China

4Bioinformatics Support Program, The Cushing/Whitney Medical Library, Yale University School of Medicine, New Haven, CT, USA

5Beijing Huilongguan Hospital, Peking University Huilongguan Clinical School of Medicine, Beijing, China

6Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China

7Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

8Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

*Corresponding Author: Xiaoping Wang, Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China and Xiaoyun Guo, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA and Xingguang Luo, Beijing Huilongguan Hospital, Peking University Huilongguan Clinical School of Medicine, Beijing, China.
Received: February 11, 2023; Published: February 22, 2023



Background: Post-stroke depression (PSD) is a mental health condition that can develop after a stroke, with a higher risk of death and negative outcomes. However, limited research has explored how PSD incidence relates to brain locations in Chinese patients. This study aims to fill this gap by examining the link between PSD occurrence and brain lesion location, as well as the type of stroke experienced by the patient.

Methods: We conducted a systematic search in databases to gather post-stroke depression literature published between January 1, 2015 and May 31, 2021. Following this, we performed a meta-analysis using RevMan to analyze the incidence of PSD associated with different brain regions and types of stroke separately.

Results: We analyzed seven studies, with a total of 1604 participants. Our findings indicated that the incidence of PSD was higher when the stroke occurred in the left hemisphere compared to the right hemisphere (RevMan: Z = 8.93, P < 0.001, OR = 2.69, 95% CI: 2.16 - 3.34, fixed model); PSD was more common when the stroke affected the cerebral cortex rather than the subcerebral cortex (RevMan: Z = 3.96, P < 0.001, OR = 2.00, 95% CI: 1.42 - 2.81) and when it affected the anterior cortex compared to the posterior cortex (RevMan: Z = 3.85, P < 0.001, OR = 1.89, 95% CI: 1.37 - 2.62). However, we did not find a significant difference in the occurrence of PSD between ischemic and hemorrhagic strokes (RevMan: Z = 0.62, P = 0.53, OR = 0.02, 95% CI: -0.05 - 0.09).

Conclusion: Our findings revealed a higher likelihood of PSD in the left hemisphere, specifically in the cerebral cortex and anterior region.

Keywords: Lesion Location; Post-Stroke Depression; Cortex; Systematic Review

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Xiaoping Wang., et al. Association of Lesion Location with Post-Stroke Depression in China: A Systematic Review and Meta-Analysis. EC Psychology and Psychiatry 12.3 (2023): 34-45.

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